Anesthesia: Essays and Researches  Login  | Users Online: 362 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Home | About us | Editorial board | Ahead of print | Search | Current Issue | Archives | Submit article | Instructions | Copyright form | Subscribe | Advertise | Contacts

Table of Contents  
Year : 2017  |  Volume : 11  |  Issue : 1  |  Page : 1-2  

Clinical considerations of intrapulpal anesthesia in pediatric dentistry

1 Department of Conservative Dentistry and Endodontics, SRM Dental College and Hospital, Ramapuram Campus, SRM University, Chennai, Tamil Nadu, India
2 Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, MAHER University, Chennai, Tamil Nadu, India
3 Department of Oral Medicine and Radiology, SRM Kattankulathur Dental College and Hospital, Chennai, Tamil Nadu, India

Date of Web Publication16-Feb-2017

Correspondence Address:
Saravana Karthikeyan Balasubramanian
Department of Conservative Dentistry and Endodontics, SRM Dental College and Hospital, Ramapuram Campus, SRM University, Chennai, Tamil Nadu
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aer.AER_11_17

Rights and Permissions

How to cite this article:
Balasubramanian SK, Natanasabapathy V, Vinayachandran D. Clinical considerations of intrapulpal anesthesia in pediatric dentistry. Anesth Essays Res 2017;11:1-2

How to cite this URL:
Balasubramanian SK, Natanasabapathy V, Vinayachandran D. Clinical considerations of intrapulpal anesthesia in pediatric dentistry. Anesth Essays Res [serial online] 2017 [cited 2020 Sep 18];11:1-2. Available from:

During endodontic treatment, effective anesthesia of any vital pulp tissue present in the pulp chamber or root canals is important for patient's cooperation and to maintain the comfort level. This is particularly true in cases of pediatric patients, where ineffective analgesia might result in a traumatic experience for the kids leading to increased apprehensiveness, reduced pain threshold, inadequate cooperation, and also creates an embarrassing situation for the dentists. The most commonly used local anesthetic solution in pediatric endodontics is 2% lidocaine hydrochloride with adrenaline (1:100,000) because of its improved efficacy at low concentrations and decreased allergenic characteristics.[1] The intrapulpal injection technique (IPI) is one of the commonly employed supplemental anesthetic technique adjuvant to conventional maxillary infiltration anesthesia or mandibular inferior alveolar block in situ ations, where patients encounter severe pain or discomfort during pulp extirpation, especially in acutely inflamed molars.[2] Although various supplemental techniques such as intraligamentary or intraosseous techniques are available, it is wise to anticipate that in spite of apparently profound anesthesia, an IPI may be required to obtain total analgesia.[3] In general, the deposition of local anesthetic solution directly into the pulp chamber provides an effective anesthesia for extirpation, instrumentation, and debridement of pulpal tissues. The most significant factor contributing to the success of IPI is that its administration must be done under pressure. Birchfield and Rosenberg suggested that the anesthetic effect of the intrapulpal technique is mainly due to the back-pressure of the solution, independent of the type of solution injected.[4] However, when the exposure site is too large for a snug needle fit, the exposed pulp is flooded with a small amount of local anesthetic solution for a minute, premature to advancing the needle as far apically as possible into the pulp chamber and injecting under pressure.[5] Various suggested methods that aid in pressure build up in such cases include, obliteration of a large pulpal opening with either gutta-percha or a cotton pellet.[5] Nevertheless, the precise mechanism by which pressure can induce anesthesia is incompletely understood. Monheim has suggested that prolonged pressure may lead to degeneration of nerve fibers in many instances leading to profound anesthesia for long endodontic treatment procedures, as in cases of pediatric patients.[6] Following access cavity preparation and deroofing of pulp chamber, IPI is administered followed by effective hemostasis which is usually achieved with a cotton wool pledge soaked with anesthetic solution or hemostatic agents such as Racellet pellets, aluminum chloride, or with sodium hypochlorite (NaOCl). In addition to its use as a hemostatic agent, NaOCl (in concentrations ranging from 0.5% to 5.25%) have been widely employed as the gold standard irrigant for pulp tissue dissolution in endodontics.[7] The pediatric dentists are aware of significant interactions between various endodontic irrigants, i.e., NaOCl and chlorhexidine (CHX), NaOCl and ethylenediaminetetracetic acid (EDTA), CHX and EDTA, but the interaction between the local anesthetic solution and subsequently used irrigants are often overlooked in clinical situations in many instances.[8],[9],[10] However, a careful review of literature revealed a study conducted by Vidhya et al. who evaluated the chemical interaction between lidocaine hydrochloride (with and without adrenaline) and NaOCl using nuclear magnetic resonance spectroscopy and reported the formation of a toxic precipitate, 2,6-xylidine, which is a known carcinogen.[11] Although all clinicians neglect this significant interaction attributing to the reason that, only a small amount of local anesthetic solution (0.2–0.5 ml) is employed for IPI, acutely inflamed pulp remnants might necessitate frequent such IPI administrations until the hot tooth is completely devoid of vital tissues to ensure the patient's maximum comfort. This is a true unacceptable fact because every dentist strives hard to perform pulp therapy in pediatric patients, for effectively putting the concerned tooth to sleep, thereby avoiding any further interventional and expensive management techniques such as conscious sedation, general anesthesia, and other behavioral management methods. Hence, the subsequent use of NaOCl (as a hemostatic agent or an irrigant) following IPI with lidocaine hydrochloride (with or without adrenaline) should be avoided in clinical cases to prevent such potential interactions. In addition, 0.9% normal saline can be preferably used to lidocaine hydrochloride for intrapulpal anesthesia (as stated by Birchfield and Rosenberg) to avoid unfavorable circumstances.[4] The IPI technique serves as a useful means of overcoming failure in teeth where conventional anesthetic techniques have failed, with an added advantage of causing negligible systemic effects. However, the main drawback with IPI technique as stated by Malamed is that the IPI by itself can be highly painful.[12] This can be attributed to the vascular distension of the tissues, i.e., engorgement of the blood vessels as stated by Harris.[13] Recently, Sooraparaju et al. in a clinical study reported that topical application of 20% benzocaine gel mixed with hyaluronidase, to the exposed pulp before the administration of IPI can reduce the intensity of pain during IPI.[14] Hyaluronidase is an enzyme that acts by hydrolysis of hyaluronic acid, a normal component of connective tissue, thereby enhancing the diffusivity of drugs injected along with it.[15] In addition, shorter needles have also been recommended in an attempt to reduce pain during injection, especially for the young uncooperative patients.[16] Therefore, a short (20 mm) or an extra shot (10 mm) 30-gauge needle can be employed in such cases to render a painless IPI. These clinically significant observations should be considered during the administration of intrapulpal anesthesia with lidocaine HCl, particularly, in cases of endodontic management of young permanent molars for rendering safe, painless, and successful pulpectomy procedures.

   References Top

Troutman KC. Pharmacologic management of pain and anxiety for pediatric patients. In: Wei SH, editor. Pediatric Dentistry Total Patient Care. Philadelphia: Lea and Febiger; 1985. p. 156-62.  Back to cited text no. 1
Boopathi T, Sebeena M, Sivakumar K, Harikaran J, Karthick K, Raj A. Supplemental pulpal anesthesia for mandibular teeth. J Pharm Bioallied Sci 2013;5 Suppl 1:S103-8.  Back to cited text no. 2
Ingle JI, Beveridge EE. Endodontics. 2nd ed. Philadelphia: Lea and Febiger; 1976. p. 211.  Back to cited text no. 3
Birchfield J, Rosenberg PA. Role of the anesthetic solution in intrapulpal anesthesia. J Endod 1975;1:26-7.  Back to cited text no. 4
VanGheluwe J, Walton R. Intrapulpal injection: Factors related to effectiveness. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;83:38-40.  Back to cited text no. 5
Monheim LM. Local Anesthesia and Pain Control in Dental Practice. 3rd ed. St. Louis: CV Mosby Co.; 1965. p. 136-8.  Back to cited text no. 6
Zehnder M. Root canal irrigants. J Endod 2006;32:389-98.  Back to cited text no. 7
Basrani BR, Manek S, Sodhi RN, Fillery E, Manzur A. Interaction between sodium hypochlorite and chlorhexidine gluconate. J Endod 2007;33:966-9.  Back to cited text no. 8
Grande NM, Plotino G, Falanga A, Pomponi M, Somma F. Interaction between EDTA and sodium hypochlorite: A nuclear magnetic resonance analysis. J Endod 2006;32:460-4.  Back to cited text no. 9
Rasimick BJ, Nekich M, Hladek MM, Musikant BL, Deutsch AS. Interaction between chlorhexidine digluconate and EDTA. J Endod 2008;34:1521-3.  Back to cited text no. 10
Vidhya N, Karthikeyan BS, Velmurugan N, Abarajithan M, Nithyanandan S. Interaction between lidocaine hydrochloride (with and without adrenaline) and various irrigants: A nuclear magnetic resonance analysis. Dent Res J (Isfahan) 2014;11:395-9.  Back to cited text no. 11
Malamed SF. The management of pain and anxiety. In: Cohen S, Burns RC, editors. Pathways of the Pulp. 7th ed. St. Louis: CV Mosby Co.; 1988. p. 665-6.  Back to cited text no. 12
Harris MH. The use of local anesthesia in the presence of inflammation. Oral Surg Oral Med Oral Pathol 1964;18:16-23.  Back to cited text no. 13
Sooraparaju SG, Abarajithan M, Sathish ES, Suryakumari NB, Ealla KK, Gade W. Anaesthetic efficacy of topical benzocaine gel combined with hyaluronidase for supplemental intrapulpal injection in teeth with irreversible pulpitis – A double blinded clinical trial. J Clin Diagn Res 2015;9:ZC95-7.  Back to cited text no. 14
Eckenhoff JE, Kirby CK. The use of hyaluronidase in regional nerve blocks. Anesthesiology 1951;12:27-32.  Back to cited text no. 15
Simon JF, Peltier B, Chambers D, Dower J. Dentists troubled by the administration of anesthetic injections: Long-term stresses and effects. Quintessence Int 1994;25:641-6.  Back to cited text no. 16


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article

 Article Access Statistics
    PDF Downloaded177    
    Comments [Add]    

Recommend this journal