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ORIGINAL ARTICLE
Year : 2017  |  Volume : 11  |  Issue : 4  |  Page : 969-975

The influence of two different doses of magnesium sulfate on intraocular pressure variations after injection of succinylcholine and endotracheal intubation: A prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial


1 Department of Anaesthesiology, Faculty of Medicine, Fayoum University, Fayuom, Egypt
2 Department of Anaesthesiology, Faculty of Medicine, Benha University, Benha, Egypt
3 Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt
4 Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
5 Department of Ophthalmology, Research Institute of Ophthalmology, Cairo, Egypt

Correspondence Address:
Hany Mahmoud Yassin
303 (T) Hadaek Al-Ahram, P.O. Box: 12572, Giza
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aer.AER_35_17

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Background The use of succinylcholine for rapid sequence induction in patients with open globe injuries may be detrimental to the eye. Aim: The aim of this study is to determine if the premedication with magnesium sulfate (MgSO4) could attenuate the increase in intraocular pressure (IOP) associated with succinylcholine injection and intubation. Setting: Operation theaters in a tertiary care University Hospital between December 2014 and July 215. Design: This was a prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial. Participants: One hundred and thirteen patients' physical status ASA Classes I and II underwent elective cataract surgery under general anesthesia. Patients and Methods: These patients allocated into three groups: Group C (control group) received 100 ml normal saline, Group M1 received 30 mg/kg MgSO4in 100 ml normal saline, and Group M2 received 50 mg/kg MgSO4in 100 ml normal saline. IOP, mean arterial pressure (MAP), and heart rate (HR) reported at 5-time points related to study drug administration. In addition, any adverse effects related to MgSO4were recorded. Intragroup and between-groups differences were examined by analysis of variance test. Results: We noticed a significant decrease in IOP in M1 (n = 38) and M2 (n = 37) groups as compared with C group (n = 38) after study drugs infusion, 2 and 5 min after intubation, P < 0.001. While the difference between M1 and M2 groups was insignificant, P = 0.296 and P = 0.647, respectively. There was a significant decrease in MAP and HR in M1 and M2 groups as compared with C group 2 and 5 min after intubation, P = 0.01. While the difference between M1 and M2 groups was insignificant, P = 1. Conclusion: MgSO4 30 mg/kg as well as 50 mg/kg effectively prevented the rise in IOP, MAP, and HR associated with rapid sequence induction by succinylcholine and endotracheal intubation.


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