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Year : 2018  |  Volume : 12  |  Issue : 1  |  Page : 1-6  

Anesthetic considerations for carotid endarterectomy: A postgraduate educational review

Department of Anesthesiology and Intensive Care Unit, University of Debrecen, Debrecen, Hungary

Date of Web Publication9-Mar-2018

Correspondence Address:
Dr. Ahmed Yousef A Al Sultan
Simonyi Street, Debrecen City, Postal Code: 4028
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aer.AER_217_17

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Carotid endarterectomy (CEA) has shown a significant benefit in preventing ipsilateral stroke when it is compared to conservative management. Surgical morbidity and mortality must be kept to a minimum to achieve this benefit. Neurological status of the CEA patients can be monitored easily during regional anesthesia depending on the awake testing (neurocognitive assessment) method of the CEA patients. In addition, specific parameters can help us to monitor and to predict the neurological status of the CEA patients during the procedures such as regional cerebral oxygen saturation (rSO2) and middle cerebral artery velocity (MCAv) changes. We conducted a computerized literature search involving humans, published in English until December 2017, and indexed through Medical Databases; MEDLINE/PubMed, EMBASE, and Web of Science. We reviewed articles performed for prospective and other types of studies related to CEA procedures and techniques which can predict patient's status during the procedure. Searching relevant articles and discussing the results to allow meaningful rate comparison, and to conclude a result view which benefits the CEA patients and the medical staff during the CEA procedures. In total, studies observed cerebral rSO2and MCAv have significant value during CEA procedures. Patients with neurological symptoms during the procedures showed changes of cerebral rSO2and MCAv more than the patients without neurological symptoms. Mentioned parameters (cerebral rSO2and MCAv) showed significant increasing right after the procedure. Mostly, CEA surgeries under local anesthesia were observed, for monitoring patients' consciousness status and comparing it to patients who undergo general anesthesia, to view the reliability of these techniques during CEA procedures, and to predict and avoid intraoperative neurological symptoms.

Keywords: Awake testing, carotid endarterectomy, cerebral monitoring, cerebral oximetry, transcranial Doppler

How to cite this article:
Al Sultan AY, Alsubhi AM. Anesthetic considerations for carotid endarterectomy: A postgraduate educational review. Anesth Essays Res 2018;12:1-6

How to cite this URL:
Al Sultan AY, Alsubhi AM. Anesthetic considerations for carotid endarterectomy: A postgraduate educational review. Anesth Essays Res [serial online] 2018 [cited 2019 Jan 19];12:1-6. Available from:

   Introduction Top

Carotid endarterectomy (CEA) has shown a significant benefit in preventing ipsilateral stroke when it is compared to conservative management. Surgical morbidity and mortality must be kept to a minimum to achieve this benefit. Neurological status of the CEA patients can be monitored easily during regional anesthesia depending on the awake testing (neurocognitive assessment) method, and completely monitored, most medical centers consider awake testing as an essential method. In addition, specific parameters can help us to monitor and predict the neurological status of CEA patients during the procedures such as regional cerebral oxygen saturation (rSO2) and middle cerebral artery velocity (MCAv) changes, aiming to find a relationship between cerebral rSO2 and MCAv and the intraoperative neurological symptoms and evaluating the reliability of intraoperative cerebral monitoring techniques to expect the need for shunting during CEA procedures, including a comparison of near-infrared spectroscopy (NIRS) and transcranial-Doppler (TCD) to any other intraoperative cerebral monitoring systems; and on either symptomatic or asymptomatic patient to achieve better intraoperative controlling during CEA procedures.[1],[2] Clinical studies considering the triple assessment method consisting of NIRS, TCD, and awake testing in detecting cerebral ischemic symptoms have the best outcome of controlling symptoms during CEA surgeries.

   Methodology Top

We conducted a computerized literature search involving humans, published in English until December 2017, and indexed through Medical Databases; MEDLINE/PubMed, EMBASE, and Web of Science. We reviewed articles performed for prospective and other types of studies related to CEA procedures and techniques which can predict patient's status during the procedure. Searching relevant articles and discussing the results to allow meaningful rate comparison, and to conclude a result view which benefits the CEA patients and the medical staff during CEA procedures. The search strategy combined the following terms and keywords: “CEA or carotid endarterectomy,” “TCD or transcranial-Doppler,” “NIRS or near-infrared spectroscopy,” and “cerebral oximetry.” When more than one publication was identified referring to the same result data, the first publication was selected. Non-English articles excluded and if articles included animals they did not fulfill inclusion criteria, and they were, therefore, not considered eligible for inclusion in the study. Furthermore, we searched the reference lists of articles identified by this search.

Statistical analysis (data extraction)

A type of systematic literature search in relating to NIRS and TCD monitoring during CEA surgeries was performed in MEDLINE/PubMed, EMBASE, and Web of Science databases, including prospective studies on NIRS and TCD for brain monitoring during CEA surgeries, plus, a comparison of NIRS and TCD to other intraoperative cerebral monitoring systems. We identified studies focused on the prediction of intraoperative cerebral ischemia and shunt indication. No threshold could be achieved for selective shunting to be determined since shunting criteria varied considerably across studies. The following data were extracted from all papers independently by the review authors: number of patients; type of anesthesia; usage of shunts; year of publication; and procedural complications. CEA papers (studies) included in this analysis are summarized in [Table 1] with the inclusion of the number of patients included in each article, the monitoring device used, and whether cerebral rSO2 and MCAv were changed intraoperatively. The total number of the CEA studies was 13 papers, yielding a group of 1662 patient undergoing review.
Table 1: In section “statistical analysis (data extraction)” as additional material

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Carotid endarterectomy procedure

Carotid endarterectomy versus conservative therapy

CEA surgery has been maintained as the foundation treatment in carotid stenosis patients having a high percentage of occlusion. The North American Symptomatic Carotid Endarterectomy Trial, the European Carotid Surgery Trial, and VA Cooperative Study randomized studies showed a significant benefit of CEA in stroke prevention. At the point when stenosis of the internal carotid artery is over 70% or equal, CEA shows markedly reducing stroke rate in patients with symptomatic lesions. The CEA benefits achieved only if morbidity and mortality of the operation is <5%. Patients with nonsymptomatic carotid stenosis are operated if they are going to have major surgery (cardiac surgery) only and performed as prophylactic only if it goes with <3% of morbidity and mortality. Operating a stenosis <70% is not beneficial if it is compared to conservative therapy because it is needed to consider the factors affecting the surgery. Including morbidity and mortality of the procedure as it plays a significant role in CEA results. If those factors in CEA are <3%, the stroke risk will drop by 81%. Therefore, those factors need to be considered and cannot be neglected before performing the procedure. However, more studies are under investigation for that matter.[3] Asymptomatic patients need to be treated with intensive medical therapy rather than going under CEA procedure because intervention for asymptomatic stenosis patients without significant need has high clinical risks and because it has more risks than benefits which can be regarded as unethical. Stenting should be performed for asymptomatic carotid stenosis (ACS) with high-risk features for instant anatomical features that make endarterectomy more difficult. Among the few percent of patients with high-risk, for example, microemboli feature better to be treated by CEA than by stenting.[4] With conservative treatment applied, specialists have analyzed that stroke rates in patients with ACS have declined during 10 years of observation. Rates have tumbled to around 1% every year in patients conservatively treated. However, in this manner, we should question whether CEA has any beneficial role in patients with ACS.[5],[6] Topakian et al. at his study in 2011 detailed in one investigation of 435 patients with ACS (>70% stenosis through ultrasound), just ten patients (2%) had strokes. Four of these strokes happened in patients with both echolucent plaques and only in those having embolic signs.[7] CEA has no beneficial results in acute attacks or stroke because of high bleeding risk related to the procedure. Only patients with unstable ischemic attacks situation which can turn into significant stroke may take the chance to perform CEA procedure.[8]


Regional anesthesia versus general anesthesia

The awake patient's response test is a superior technique for monitoring patient's need for shunting during CEA. Because the awake assessment method used during regional anesthesia can avoid any shunts malfunction incidence (shunt-related stroke) that may occur in GA with routinely shunt using protocol during CEA procedures. Besides, CEA procedures using GA increases postoperative complications in those patients with myocardial issues.[9],[10] Between 1968 and 1975, 290 patients were observed under CEA, divided into two groups one with general anesthesia and the second group with regional anesthesia; the first group consisting of 188 patients performed the CEA procedure with keeping shunt in all CEA patients. Three deaths were recorded in this category, plus some complications of motor impairment and weakness of extremities. In the second group, 102 patients were under regional anesthesia plus an intraoperative assessment of consciousness and stump pressure use, no deaths in this category neither motor or consciousness impairment were recorded. This study showed the absolute need for intraoperative evaluation in combination with stump pressure to avoid CEA complications.[11],[12] Although regional anesthesia gives the assurance for shunting need, some medical centers prefer general anesthesia in combination to cervical plexus blockage, as it provides more controlled environment during surgeries, adding to that it allows rapid interfering just in case of sudden respiratory and blood pressure changing.[13],[14]

Monitoring techniques

Vascular evaluations using stump pressure

Stump pressure is a technique used to evaluate the need for shunting during CEA surgeries; this method is depending on measuring the back pressure in the distal part of the internal carotid artery after clamping. As the recorded reading of the back pressure in the targeted artery, the need for shunting was decided.[15],[16] Stump pressure values >25 mmHg shows the safe level as it was thought in the past years, later it was revised to mean of 40 mmHg as the safe level.[17],[18] On the contrary, different studies recorded few patients had consciousness impairment (shunt requirement) even when stump pressure was giving records reach to 50 mmHg and greater, plus the technique showed some percentage of unnecessary need for shunt records in different clinical studies. Therefore, stump pressure considered as an inadequate technique and has poor sensitivity because of the noticed clinical situations opposite to the assuring readings by this technique. Stump pressure has faced dissatisfaction in some medical centers for the mentioned reason.[19],[20]

Transcranial Doppler monitoring

TCD ultrasonography was introduced in clinics in the early eighties for the first time. TCD is a noninvasive monitoring technique involving the use of ≤2 MHz transducers, placed on the skull of the patient, through temporal bone windows (relatively thin bone) to measure the cerebral blood flow velocity and its alterations. The method is repeatable, allows continuous bedside monitoring of cerebral blood flow velocity, which is particularly useful in the intensive care setting. TCD has a significant role in the early phases of cerebral pathology.[21] Pulsed Doppler sectorial probe is the most used transducer in practice. Using a 2.0–3.5 MHz frequency waves, an adjustment of the probe to the scalp through a headband to keep the angle of insonation for maintaining continuous recording. Middle cerebral artery (MCA) is the most intracranial artery examined by TCD method because it is easily detected through the temporal window. MCA has vital importance in this technique because it collects about 60%–70% of the internal carotid artery blood flow. About 45–60 mm of depth needed to detect MCA. Moreover, about 50 ± 20 s of time required to achieve MCA echographic image on TCD monitor.[22]

INVOS™ cerebral oximeter monitoring

INVOS™ monitoring is an adjunctive noninvasive method which is intended for regional rSO2 monitoring in the brain or other targeted tissue through a sensor. The INVOS monitoring can be considered as an initial diagnostic method only but not used for confirming diagnostic purposes. INVOS monitoring has a significant role in improving patient management and outcomes after surgeries.[23] Intracranial rSO2 can be measured by NIRS as the human tissues are translucent to infrared light emitted through NIRS system.[24] Two disposable sensors (photodetector) with a near-infrared light source in each patch that can be applied on the forehead for monitoring purpose. Proprietary method called spatial resolution used to avoid the effect of extracerebral reflected photons. Regional rSO2 readings are machine-specific and are not variable among distinct brands of oximeter devices.[25]


Smoking: Association of decreased blood vessels compliance, HDL levels, high-platelet aggregation, hematocrit, and fibrinogen levels is noticed in smokers. About 18% of strokes are associated with nicotine smoking. Atherosclerosis was higher in progression in both active and passive smokers. Risk of using oral contraceptives by smokers should be considered as it increases the risk of strokes.[26],[27] Hypertension and high cholesterol levels: Hypertension is the most prominent modifiable risk factor for ischemic stroke. Association of high total cholesterol, triglycerides, low LDL cholesterol is considered, especially atherosclerotic and lacunar stroke subtypes are noticed in ischemic stroke patients.[26],[28] Diabetes: Diabetes increases the risk of ischemic stroke in different races at different rates. 22% of prevalence in elderly “African” people, and 20% of older Hispanics, with attributable stroke risks of 13% and 20%, correspondingly. Moreover, this is related to insulin-resistance mechanism as healthy individuals with high insulin levels have a higher relative risk of stroke.[29],[30] Buerger's disease: Stroke and Buerger's disease has an infrequent connection, but the pathological base is associated.[26] Vasculitis: Due to the inflammation of cerebral vessels, a stroke may arise with higher incidence. Transient ischemic attack is also frequent in these patients.[26] Radiotherapy Complication: Head-and-neck tumor radiotherapy is associated relatively by two folds to ischemic stroke risk. Different size cranial arteries are prone to significant stenosis in patients with chronic radiotherapy treatments. Radiation affects directly intima media and intima adventitia which in turn leads to vasa vasorum defects and atherosclerosis results.[31]

Pathomechanism of atherosclerosis

Atherosclerosis starts as disruption of endothelial integrity due to physical injury or metabolic stress. Alteration in expression of cellular adhesion and surface molecules vascular cell adhesion molecule 1 and intercellular adhesion molecule which result in dysregulation of blood cells adhesion. Changes in cell membrane permeability will appear which results in adherence and degranulation of platelet cells at the adluminal surface of blood vessels. Platelets begin releasing growth factors targeting smooth muscles leading them to proliferate at vascular surface making a new layer (neointima). Subsequent recruitment occurs leads to atherosclerosis due to platelets adhesiveness and degranulation.[32] Endothelial and smooth muscle cells start to alter their physiologic functions and start to secrete pro-inflammatory signals and cytokines. So-called lipid-laden macrophages will show in tunica media because of their high demand function at the site, and the repeated damage will result in atherosclerotic plaque and fatty streaks formation.[33],[34]

Comparisons between methods reliability

There are many techniques for cerebral monitoring during CEA procedures, for example, TCD, NIRS, electroencephalography, somatosensory-evoked potential, carotid artery stump pressure, and awake test (neurocognitive assessment) that can help us predicting the need for a shunt during CEA surgeries. However, the awake testing is the gold standard method among these techniques of cerebral monitoring.[35],[36],[37],[38] Former studies confirmed a strong correlation between MCAv, cerebral rSO2, and neurological status during CEA.[39],[40],[41] Stilo et al. at his study in 2012 showed a significant correlation between cerebral rSO2 changes and the loss of cortical functions right after clamping stage in CEA procedures.[42],[43] A decrease in rSO2 of more than 20% may indicate the need for shunt during CEA.[44] Shahidi et al. at his study in 2017 indicated stump pressures role in a study of 120 patients, stump pressure readings of mean 40 mmHg were predicted and considered to be safe.[18],[45],[46] For demonstrating the role of TCD in CEA, Navarro et al. at his systematic review in 2007 showed a great relation between TCD and shunt need during CEA procedures reviewing articles between (1982 and 2005).[47] TCD is a safe cerebral monitoring during CEA and it can predict the need to use of carotid shunt.[48],[49]

   Conclusion Top

Data in the studies observed gave us a general idea of how the NIRS, TCD, and other intraoperative monitoring methods could be sensitive and have a high value during CEA procedures. Studies observed were intended to compare intraoperative monitoring methods to help in detecting cerebral ischemia, especially cerebral oximetry/NIRS, and TCD contrasted with alert testing (awake neurocognitive assessment) in recognizing the requirement for shunting in CEA procedures. Cerebral oximetry/NIRS showed high changes and can be used for all patients which it can be counted to its pros. TCD showed high changes as well, but screening availability is limited to patients with temporal window only, which consider as a usage limitation. Clinical studies considering the triple assessment method as best (combination of NIRS, TCD, and awake testing) in detecting cerebral ischemic symptoms and it has best outcome of controlling symptoms during CEA surgeries.


I acknowledge and offer the sincerest gratitude to Dr. Gyöngyösi Zoltán and Prof. Dr. Fülesdi Béla for supporting and allowing contribution to writing this review with the Department of Anesthesiology and Intensive Care.

Financial support and sponsorship

This study was financially supported by University of Debrecen.

Conflicts of interest

There are no conflicts of interest.

   References Top

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