| CASE REPORT |
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| Year : 2015 | Volume
: 9
| Issue : 3 | Page : 427-429 |
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Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure
Rudrashish Haldar1, Ashutosh Kaushal1, Devendra Gupta1, Shashi Srivastava1, Prabhat K Singh1, Paurush Ambesh2
1 Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
2 Department of Internal Medicine, Motilal Nehru Medical College, Allahabad, Uttar Pradesh, India
Correspondence Address:
Rudrashish Haldar
Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow - 226 014, Uttar Pradesh
India
 Source of Support: Nil, Conflict of Interest: None declared.  | Check |
DOI: 10.4103/0259-1162.159773
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Ceftazidime is a widely used antibiotic with broad spectrum activity against Gram-positive and Gram-negative microbes and is used prophylactically in neurosurgical patients prior to surgery. Neurotoxicity is a recognized complication of ceftazidime use but is reported predominantly after repeated administration in patients with impaired renal status. We encountered a patient with an intracranial tumor who developed generalized convulsions following a single dose of ceftazidime, which was infused rapidly and attempt to provide an explanation of this uncommon occurrence.
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