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CASE REPORT
Year : 2015  |  Volume : 9  |  Issue : 3  |  Page : 427-429

Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure


1 Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
2 Department of Internal Medicine, Motilal Nehru Medical College, Allahabad, Uttar Pradesh, India

Correspondence Address:
Rudrashish Haldar
Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow - 226 014, Uttar Pradesh
India
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Source of Support: Nil, Conflict of Interest: None declared.


DOI: 10.4103/0259-1162.159773

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Ceftazidime is a widely used antibiotic with broad spectrum activity against Gram-positive and Gram-negative microbes and is used prophylactically in neurosurgical patients prior to surgery. Neurotoxicity is a recognized complication of ceftazidime use but is reported predominantly after repeated administration in patients with impaired renal status. We encountered a patient with an intracranial tumor who developed generalized convulsions following a single dose of ceftazidime, which was infused rapidly and attempt to provide an explanation of this uncommon occurrence.


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