Anesthesia: Essays and Researches  Login  | Users Online: 521 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Home | About us | Editorial board | Ahead of print | Search | Current Issue | Archives | Submit article | Instructions | Copyright form | Subscribe | Advertise | Contacts

Table of Contents  
Year : 2016  |  Volume : 10  |  Issue : 3  |  Page : 689-690  

Caffeine for delayed recovery

Department of Anaesthesiology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India

Date of Web Publication27-Sep-2016

Correspondence Address:
Madhuri S Kurdi
Karnataka Institute of Medical Sciences, Hubli, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0259-1162.186867

Rights and Permissions

How to cite this article:
Kurdi MS. Caffeine for delayed recovery. Anesth Essays Res 2016;10:689-90

How to cite this URL:
Kurdi MS. Caffeine for delayed recovery. Anesth Essays Res [serial online] 2016 [cited 2021 May 10];10:689-90. Available from:


I read with interest the postgraduate educational review on “delayed recovery from anesthesia”[1] in the May 2016 issue of your journal. Delayed recovery is a problem that every anesthesiologist will encounter sometime in his practice. At such times, a good knowledge of the causes, evaluation, and management of “delayed recovery” can be a great support. In their article, the authors have given a very elaborate account of delayed recovery from both general and regional anesthesia. I would like to add one more class of drugs – cyclic adenosine monophosphate (AMP) elevating drugs to the management of delayed recovery.

General anesthetics inhibit neurotransmitter release from both neurons and secretory cells. Intracellular cyclic AMP-elevating drugs such as forskolin, theophylline, and caffeine are known to facilitate neurotransmitter release. They were all found to dramatically accelerate recovery from isoflurane anesthesia when tested in isoflurane anesthetized rats; nevertheless, caffeine was the most effective.[2] Caffeine alone when tested on propofol anesthetized rats was found to dramatically accelerate the recovery from anesthesia.[2] In another study, intravenous 500 mg caffeine benzoate injected after the completion of surgery and the discontinuation of sevoflurane in adult patients with obstructive sleep apnea undergoing uvulopalatopharyngoplasty was found to decrease the occurrence of adverse postextubation adverse respiratory events and hastens recovery from sevoflurane anesthesia.[3] Evidence exists that caffeine might have a positive influence on early recovery of postoperative bowel activity and thus shorten hospital stay after colon surgery. Randomized controlled trials are being conducted by some researchers on this topic.[4] Caution should be exercised when administering caffeine to patients with cardiac insufficiency, cardiac arrhythmias, compromised liver function, pregnancy, and lactation.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Misal US, Joshi SA, Shaikh MM. Delayed recovery from anesthesia: A postgraduate educational review. Anesth Essays Res 2016;10:164-72.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
Wang Q, Fong R, Mason P, Fox AP, Xie Z. Caffeine accelerates recovery from general anesthesia. J Neurophysiol 2014;111:1331-40.  Back to cited text no. 2
Gouda NM. Intravenous caffeine for adult patients with obstructive sleep apnea undergoing uvulopalatopharyngoplasty: Effects on postoperative respiratory complications and recovery profile. Med J Cairo Univ 2010;78:155-9.  Back to cited text no. 3
Kruse C, Müller SA, Warschkow R, Lüthi C, Brunner W, Marti L, et al. Does caffeine reduce postoperative bowel paralysis after elective laparoscopic colectomy? (CaCo trial): Study protocol for a randomized controlled trial. Trials 2016;17:186.  Back to cited text no. 4


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article

 Article Access Statistics
    PDF Downloaded78    
    Comments [Add]    

Recommend this journal