|Year : 2017 | Volume
| Issue : 2 | Page : 499-502
The analgesic efficacy of dexamethasone added to ropivacaine in transversus abdominis plane block for transabdominal hysterectomy under subarachnoid block
Jyoti P Deshpande, Poonam S Ghodki, Shalini P Sardesai
Department of Anesthesia, Shrimati Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra, India
|Date of Web Publication||16-May-2017|
Jyoti P Deshpande
Flat No. B-401, Jubilee Park Society, Sr. No. 83/1, Warje, Pune - 411 058, Maharashtra
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Background and Aims: Ultrasound-guided transversus abdominis plane (TAP) block has been proven as a safe and effective analgesic technique for several lower abdominal surgeries. Various adjuvants have been used to intensify the quality and prolong the local anesthetic effect. We evaluated the analgesic efficacy of dexamethasone addition to ropivacaine in TAP block following open abdominal hysterectomy. Materials and Methods: After clearance from the Institutional Ethics Committee, a double-blind, prospective, randomized study was carried out on sixty patients aged 40–60 years posted for elective open abdominal hysterectomy comparing bilateral TAP block using 20 ml of 0.5% ropivacaine + 1 ml of 0.9% saline (control Group R) or 20 ml of 0.5% ropivacaine + 4 mg dexamethasone (Group RD). The aim of our study was to observe postoperative pain score (visual analog scale [VAS]), time for first analgesic (TFA) demand, total analgesic consumption, and incidence of nausea or vomiting. Statistical Analysis: Chi-square test and Student's t-test were used, and P< 0.05 was considered as statistically significant. Results: Postoperative VAS pain scores were significantly lower at 4, 6, and 12 h in Group RD as compared to Group R (P < 0.05). Significantly longer TFA (13.2 ± 7.6 vs. 7.1 ± 4.6 h, P< 0.001) with lesser tramadol requirement in first 24 h (50.2 ± 34 vs. 94 ± 35 mg, P< 0.001) were observed in Group RD as compared to Group R. Incidence of nausea or vomiting was statistically insignificant between the groups (P > 0.05). Conclusions: Addition of dexamethasone to ropivacaine TAP block prolonged the postoperative analgesia and reduced analgesic requirement following abdominal hysterectomy.
Keywords: Dexamethasone, postoperative analgesia, ropivacaine, transversus abdominis plane block
|How to cite this article:|
Deshpande JP, Ghodki PS, Sardesai SP. The analgesic efficacy of dexamethasone added to ropivacaine in transversus abdominis plane block for transabdominal hysterectomy under subarachnoid block. Anesth Essays Res 2017;11:499-502
|How to cite this URL:|
Deshpande JP, Ghodki PS, Sardesai SP. The analgesic efficacy of dexamethasone added to ropivacaine in transversus abdominis plane block for transabdominal hysterectomy under subarachnoid block. Anesth Essays Res [serial online] 2017 [cited 2021 Aug 5];11:499-502. Available from: https://www.aeronline.org/text.asp?2017/11/2/499/206262
| Introduction|| |
Patients usually suffer from significant pain after abdominal surgery, with the major source of pain being the anterior abdominal wall and the abdominal viscera. These patients require a multimodal postoperative treatment regimen that provides high-quality analgesia with minimal side effects. The transversus abdominis plane (TAP) block is a regional anesthesia technique that targets the sensory nerve supply of the anterolateral abdominal wall and has been proven as an effective method to reduce postoperative pain and analgesic consumption for lower abdominal surgeries in various clinical trials., Various adjuvants have been used to intensify the quality and prolong the local anesthetic effect., Dexamethasone, through its anti-inflammatory and blocking effects on neural discharge, and nociceptor C fibers transmission could be used as a local anesthetic adjuvant. The aim of the present study was to assess the effect of dexamethasone as an adjuvant to ropivacaine on TAP block as a part of multimodal analgesia for patients undergoing open abdominal hysterectomy.
| Materials and Methods|| |
After the Ethics Committee approval and written informed consent, sixty patients of physical status American Society of Anesthesiologists Classes I or II aged between 40 and 60 years posted for elective open transabdominal hysterectomy under spinal anesthesia were enrolled in a prospective, randomized, double-blind, and controlled clinical study. Exclusion criteria included patient's refusal, allergy to study drug, contraindication to spinal anesthesia, those who required general anesthesia for surgery, morbid obesity, or chronic analgesic user.
After explaining the procedure and the nature of safety of the procedure, a written informed consent was obtained.
Patients were randomly allocated into two equal groups using a random number table generated by Microsoft Excel through sealed envelope technique to get either TAP block with 20 ml ropivacaine 0.5% +1 ml saline 0.9% (control group, Group R, n = 30) or 20 ml ropivacaine 0.5% +1 ml saline dexamethasone 4 mg (Group RD, n = 30) on either side. The patients, anesthesiologists and evaluating staff were blinded to the allotment. Standard monitoring included electrocardiogram, pulse oximetry, and noninvasive blood pressure. A 20-gauge intravenous access was established for all the patients included in the study. Under all aseptic precautions, spinal anesthesia was administered with 0.5% bupivacaine 17.5 mg (3.5 cc) intrathecally. At the end of surgery, ultrasound-guided (USG) TAP block was administered by posterior approach, in-plane technique using Sonosite NanoMaxx USG Machine. During the injection, the distribution of local anesthetic was observed as a hypoechoic enlargement on ultrasonography. All patients received intravenous paracetamol 1 g before shifting to recovery room as a part of multimodal analgesia. Pain severity was assessed by an investigator blinded to the group assignment every 2, 4, 6, 12, and 24 h using visual analog scale (VAS 0 = no pain and 10 = worst possible pain). Intravenous tramadol (1 mg/kg) was given as rescue analgesia on patient's demand or when VAS >4. Primary outcomes to be studied were time to first (TFA) request and VAS score, while secondary outcomes were 24h tramadol consumption and the occurence of nausea or vomiting. The patients were monitored and any side effects (nausea or vomiting)/complications were recorded.
For the sample size calculation, we assumed that there would be 25% absolute reduction in 24 h tramadol consumption due to dexamethasone-TAP block administration as a clinically significant end-point. This was a conservative assumption based on our pilot study and previous studies., We calculated that 24 patients in each group would be enough to detect a 25% difference between the groups (α = 0.05 and β =0.2). To cover for dropouts, we elected to recruit thirty patients per group into the study. Statistical analysis was done using the computer statistical software system, SPSS version 18.0 (SPSS Inc., Chicago, IL, USA). Numerical data were analyzed using Student's t-test. Categorical data were analyzed by Chi-square test or fisher's exact test as appropriate. Results were expressed as mean ± standard deviation, number or percentage (%). Results were considered statistically significant if P< 0.05.
| Results|| |
Out of 60 patients scheduled for open abdominal hysterectomy, 30 were randomized to undergo TAP block with 0.5% ropivacaine with dexamethasone (Group RD = 30) and remaining 30 with 0.5% ropivacaine (Group R = 30). Both the groups were comparable regarding demographic data and duration of surgery [Table 1]. Addition of dexamethasone to ropivacaine TAP block provided lower postoperative VAS pain score [Table 2], longer TFA (13.2 ± 7.6 vs. 7.1 ± 4.6 h, P< 0.001) [Table 3], lesser tramadol (50.2 ± 34 vs. 94 ± 35 mg, P< 0.001) [Table 3] requirements during postoperative 24 h, and lower incidence of nausea and vomiting (two vs. four patients, P > 0.05) as compared to control group. No complications or adverse effects related to procedure were observed.
| Discussion|| |
The present study showed that the addition of 4 mg dexamethasone to 20 ml ropivacaine 0.5% for bilateral TAP block prolonged the TFA, reduced opioid consumption, and decreased VAS pain score over postoperative 24 h in patients undergoing transabdominal hysterectomy.
Various studies were carried out to demonstrate the analgesic efficacy and safety of corticosteroids in neuroaxial and peripheral block.,,,,,,,, Kikuchi et al. reported that methylprednisolone decreased continuous pain and allodynia in patients with herpetic neuralgia more on intrathecal rather than epidural due to decreased interleukin-8. Dexamethasone has been shown to be safe and effective adjuvant for axillary, supraclavicular as well as interscalene brachial plexus block.,, TAP block is a safe and effective modality for postoperative analgesia as a part of multimodal approach to anesthesia and enhanced recovery in patients undergoing abdominal surgery., Several researches demonstrated that the dexamethasone is an effective adjuvant in TAP block.,,, Ropivacaine is well-tolerated local anesthetic agent with less toxic potential and better sensorimotor differentiation. Cummings et al. reported longer analgesia when dexamethasone was added to ropivacaine or bupivacaine for interscalene block, with the effect being more potent with ropivacaine. Hence, we decided to study dexamethasone with ropivacaine for TAP block. Ammar and Mahmoud found prolonged analgesia and decreased postoperative nausea and vomiting when dexamethasone was added to bupivacaine in TAP block for abdominal hysterectomy. Our results are in concordance with this study. Although we found lower incidence of nausea or vomiting in our study group, it was statistically insignificant. A study conducted in low-resource setting also recommends bupivacaine-dexamethasone TAP block due to its superior analgesic effect over a parenteral opioid for postoperative analgesia. Foster et al. reported that preoperative bilateral TAP block with 4 mg dexamethasone in patients undergoing total open abdominal hysterectomy reduced the postoperative narcotic requirements and adverse events with shorter length of hospital stay. Akkaya et al. studied the effect of dexamethasone with levobupivacaine in TAP block for cesarean section patients under spinal anesthesia. They observed prolonged postoperative analgesia, reduced tramadol consumption, and no considerable side effects such as nausea or vomiting. We also noted similar findings with dexamethasone-ropivacaine in TAP block for hysterectomy patients. El Sharnoubyand El Gendy conducted a study with dexamethasone and isobaric bupivacaine in TAP for laparoscopic bariatric surgeries. They found a significant improvement of analgesia as well as reduced incidence of nausea and vomiting promoting early ambulation in dexamethasone group. They also observed that the addition of 4 mg dexamethasone was equipotent to 8 mg dexamethasone for TAP block. This encouraged us to select a lower dose that is 4 mg dexamethasone for our study. In accordance with the previous studies, our study also demonstrates that the dexamethasone can be used as adjuvant with ropivacaine in TAP block when spinal additives are contraindicated or not used.
Mechanism for analgesic effect of steroids is not well understood. Corticosteroid induces analgesia through their anti-inflammatory or immunosuppressive effects., Analgesic action of steroid might be due to modulation of nuclear transcription. In addition, steroids may potentiate the action of local anesthetic through modulation of the function of the K + channels in excitable cells. Some authors also believe that the analgesic effect of corticosteroids is due to their systemic effects. A recent in vivo animal safety models show no adverse event levels and potential neuroprotection and antihyperalgesic effects with clinically relevant dosing of perineural dexamethasone to bupivacaine., Whatever, the mechanism of action, all previous studies have recommended the use of dexamethasone to potentiate analgesia and anesthesia of local anesthetic agents administered through various routes.
TAP block is a very safe and established block utilized for postoperative analgesia, with the advent of USG, it is associated with higher success rate, and incidence of complications is very rare.
The limitation of the current study is that the extent of block under spinal anesthesia could not be assessed which may be vital in assessing successful block. Delayed rescue analgesia with reduced analgesic consumption is the strength of our study. Another limitation of our study is lacking of control group to assess the beneficial effect of intravenous dexamethasone on TAP block. However, the comparison would have been difficult without monitoring serum levels of dexamethasone. A presumption can be perhaps made that intravenous dexamethasone will also have a similar effect. Extensive studies will be required to prove this hypothesis further.
| Conclusions|| |
Addition of dexamethasone to ropivacaine in TAP block prolonged the postoperative analgesia and reduced the analgesic requirements following open abdominal hysterectomy without any major side effects. We recommend the routine use of a ropivacaine-dexamethasone TAP block as part of multimodal analgesic regimen after open trans-abdominal hysterectomy to enhance the recovery process and render patient pain free.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Carney J, McDonnell JG, Ochana A, Bhinder R, Laffey JG. The transversus abdominis plane block provides effective postoperative analgesia in patients undergoing total abdominal hysterectomy. Anesth Analg 2008;107:2056-60.
Rafi AN. Abdominal field block: A new approach via the lumbar triangle. Anaesthesia 2001;56:1024-6.
Abdallah FW, Chan VW, Brull R. Transversus abdominis plane block: A systematic review. Reg Anesth Pain Med 2012;37:193-209.
Kapral S, Gollmann G, Waltl B, Likar R, Sladen RN, Weinstabl C, et al.
Tramadol added to mepivacaine prolongs the duration of an axillary brachial plexus blockade. Anesth Analg 1999;88:853-6.
Pöpping DM, Elia N, Marret E, Wenk M, Tramèr MR. Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: A meta-analysis of randomized trials. Anesthesiology 2009;111:406-15.
Vieira PA, Pulai I, Tsao GC, Manikantan P, Keller B, Connelly NR. Dexamethasone with bupivacaine increases duration of analgesia in ultrasound-guided interscalene brachial plexus blockade. Eur J Anaesthesiol 2010;27:285-8.
Akkaya A, Yildiz I, Tekelioglu UY, Demirhan A, Bayir H, Ozlu T, et al.
Dexamethasone added to levobupivacaine in ultrasound-guided tranversus abdominis plain block increased the duration of postoperative analgesia after caesarean section: A randomized, double blind, controlled trial. Eur Rev Med Pharmacol Sci 2014;18:717-22.
Mankikar MG, Sardesai SP, Ghodki PS. Ultrasound-guided transversus abdominis plane block for post-operative analgesia in patients undergoing caesarean section. Indian J Anaesth 2016;60:253-7.
] [Full text]
Glasser RS, Knego RS, Delashaw JB, Fessler RG. The perioperative use of corticosteroids and bupivacaine in the management of lumbar disc disease. J Neurosurg 1993;78:383-7.
Kopacz DJ, Lacouture PG, Wu D, Nandy P, Swanton R, Landau C. The dose response and effects of dexamethasone on bupivacaine microcapsules for intercostal blockade (T9 to T11) in healthy volunteers. Anesth Analg 2003;96:576-82.
Mirzai H, Tekin I, Alincak H. Perioperative use of corticosteroid and bupivacaine combination in lumbar disc surgery: A randomized controlled trial. Spine (Phila Pa 1976) 2002;27:343-6.
Kikuchi A, Kotani N, Sato T, Takamura K, Sakai I, Matsuki A. Comparative therapeutic evaluation of intrathecal versus epidural methylprednisolone for long-term analgesia in patients with intractable postherpetic neuralgia. Reg Anesth Pain Med 1999;24:287-93.
Movafegh A, Razazian M, Hajimaohamadi F, Meysamie A. Dexamethasone added to lidocaine prolongs axillary brachial plexus blockade. Anesth Analg 2006;102:263-7.
Shrestha BR, Maharjan SK, Tabedar S. Supraclavicular brachial plexus block with and without dexamethasone – A comparative study. Kathmandu Univ Med J (KUMJ) 2003;1:158-60.
Cummings KC 3rd
, Napierkowski DE, Parra-Sanchez I, Kurz A, Dalton JE, Brems JJ, et al.
Effect of dexamethasone on the duration of interscalene nerve blocks with ropivacaine or bupivacaine. Br J Anaesth 2011;107:446-53.
Johns N, O'Neill S, Ventham NT, Barron F, Brady RR, Daniel T. Clinical effectiveness of transversus abdominis plane (TAP) block in abdominal surgery: A systematic review and meta-analysis. Colorectal Dis 2012;14:e635-42.
Abdallah FW, Halpern SH, Margarido CB. Transversus abdominis plane block for postoperative analgesia after Caesarean delivery performed under spinal anaesthesia? A systematic review and meta-analysis. Br J Anaesth 2012;109:679-87.
Ammar AS, Mahmoud KM. Effect of adding dexamethasone to bupivacaine on transversus abdominis plane block for abdominal hysterectomy: A prospective randomized controlled trial. Saudi J Anaesth 2012;6:229-33.
] [Full text]
Moyo N, Madzimbamuto FD, Shumbairerwa S. Adding a transversus abdominis plane block to parenteral opioid for postoperative analgesia following trans-abdominal hysterectomy in a low resource setting: A prospective, randomised, double blind, controlled study. BMC Res Notes 2016;9:50.
Foster CJ, Ferguson DJ, Darnall CR. TAP blocks using dexamethasone with ropivacaine decreases inpatient hospital stay. Anesth Pain Med 2012;102:705-14.
El Sharnouby NM, El Gendy HA. Ultrasound-guided single injection transversus abdominis plane block of isobaric bupivacaine with or without dexamethasone for bariatric patients undergoing laparoscopic vertical banded gastroplasty: A comparative study of different doses. Ain Shams J Anaesthesiol 2015;8:194-9.
McCormack K. The spinal actions of nonsteroidal anti-inflammatory drugs and the dissociation between their anti-inflammatory and analgesic effects. Drugs 1994;47 Suppl 5:28-45.
Ahlgren SC, Wang JF, Levine JD. C-fiber mechanical stimulus-response functions are different in inflammatory versus neuropathic hyperalgesia in the rat. Neuroscience 1997;76:285-90.
Naghipour B, Aghamohamadi D, Azarfarin R, Mirinazhad M, Bilehjani E, Abbasali D, et al.
Dexamethasone added to bupivacaine prolongs duration of epidural analgesia. Middle East J Anaesthesiol 2013;22:53-7.
Pennington AJ, Kelly JS, Antoni FA. Selective enhancement of an A type potassium current by dexamethasone in a corticotroph cell line. J Neuroendocrinol 1994;6:305-15.
Williams BA, Butt MT, Zeller JR, Coffee S, Pippi MA. Multimodal perineural analgesia with combined bupivacaine-clonidine-buprenorphine-dexamethasone: Safe in vivo
and chemically compatible in solution. Pain Med 2015;16:186-98.
An K, Elkassabany NM, Liu J. Dexamethasone as adjuvant to bupivacaine prolongs the duration of thermal antinociception and prevents bupivacaine-induced rebound hyperalgesia via regional mechanism in a mouse sciatic nerve block model. PLoS One 2015;10:e0123459.
Weiss E, Jolly C, Dumoulin JL, Meftah RB, Blanié P, Laloë PA, et al.
Convulsions in 2 patients after bilateral ultrasound-guided transversus abdominis plane blocks for cesarean analgesia. Reg Anesth Pain Med 2014;39:248-51.
[Table 1], [Table 2], [Table 3]
|This article has been cited by|
||Effects of different doses of dexamethasone as local anesthetic adjuvant on brachial plexus block
| ||Shuai Zhang,Meiyan Song,Wei An,Zhongyi Wang |
| ||Medicine. 2021; 100(17): e25651 |
|[Pubmed] | [DOI]|
||Comparison of postoperative analgesic effects of two doses of dexamethasone in ultrasound-guided transversus abdominis plane block for inguinal hernia repair: a randomized controlled trial
| ||Amani H. Abdel-wahab,Ekram A. Osman,Abubakr Y. Ahmed |
| ||Ain-Shams Journal of Anesthesiology. 2021; 13(1) |
|[Pubmed] | [DOI]|
||To compare postoperative analgesic effect of ropivacaine with or without dexamethasone in ultra sound guided transversus abdominis plane block for patients undergoing lower abdominal surgeries - A prospective & randomized study
| ||Arnab Banerjee,Shailendra Kumar Pareek,Pradeep K Goyal |
| ||Indian Journal of Clinical Anaesthesia. 2021; 8(1): 11 |
|[Pubmed] | [DOI]|
||Combined use of transversus abdominis plane block and laryngeal mask airway during implementing ERAS programs for patients with primary liver cancer: a randomized controlled trial
| ||Hai-ming Huang,Rui-xia Chen,Lin-mei Zhu,Wen-shuai Zhao,Xi-jiu Ye,Jian-wei Luo,Fu-ding Lu,Lei Zhang,Xue-ying Yang,Yuan Yuan,Jun Cao |
| ||Scientific Reports. 2020; 10(1) |
|[Pubmed] | [DOI]|
||Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis
| ||Stephanie Weibel,Gerta Rücker,Leopold HJ Eberhart,Nathan L Pace,Hannah M Hartl,Olivia L Jordan,Debora Mayer,Manuel Riemer,Maximilian S Schaefer,Diana Raj,Insa Backhaus,Antonia Helf,Tobias Schlesinger,Peter Kienbaum,Peter Kranke |
| ||Cochrane Database of Systematic Reviews. 2020; |
|[Pubmed] | [DOI]|
||Use of Transversus Abdominis Plane Block in Cosmetic Abdominoplasties: A Systematic Review of the Literature
| ||Jude L. Opoku-Agyeman,David V. Matera,Jamee E. Simone,Amir B. Behnam |
| ||The American Journal of Cosmetic Surgery. 2020; 37(1): 37 |
|[Pubmed] | [DOI]|
||Opioid Use in the Postoperative Arena
| ||JANELLE K. MOULDER,JONATHAN D. BOONE,JASON M. BUEHLER,MICHELLE LOUIE |
| ||Clinical Obstetrics and Gynecology. 2019; 62(1): 67 |
|[Pubmed] | [DOI]|
||Dexamethasone added to local anesthetics in ultrasound-guided transversus abdominis plain (TAP) block for analgesia after abdominal surgery: A systematic review and meta-analysis of randomized controlled trials
| ||Donghang Zhang,Cheng Zhou,Dang Wei,Long Ge,Qian Li,Ashish K. Khanna |
| ||PLOS ONE. 2019; 14(1): e0209646 |
|[Pubmed] | [DOI]|
||Effect of Adding Dexmedetomidine to Bupivacaine in Ultrasound Guided Rectus Sheath Block: A Randomized Controlled Double-blinded Study
| ||Wafaa T Salem,Khaled A Alsamahy,Wael A Ibrahim,Abear S Alsaed,Mohamed M Salaheldin |
| ||The Open Anesthesia Journal. 2019; 13(1): 25 |
|[Pubmed] | [DOI]|
||Clinical analgesic efficacy of dexamethasone as a local anesthetic adjuvant for transversus abdominis plane (TAP) block: A meta-analysis
| ||Qi Chen,Ran An,Ju Zhou,Bin Yang,Stephen Choi |
| ||PLOS ONE. 2018; 13(6): e0198923 |
|[Pubmed] | [DOI]|
||Local anaesthetic pain relief therapy: In vitro and in vivo evaluation of a nanotechnological formulation co-loaded with ropivacaine and dexamethasone
| ||Yongxin Zhang,Yaocun Yue,Meng Chang |
| ||Biomedicine & Pharmacotherapy. 2017; 96: 443 |
|[Pubmed] | [DOI]|
||Analysis of efficacy of adding dexamethasone to ropivacaine in oral surgery
| ||Simona Stojanovic |
| ||Acta stomatologica Naissi. 2017; 33(76): 1754 |
|[Pubmed] | [DOI]|