Anesthesia: Essays and Researches  Login  | Users Online: 273 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Home | About us | Editorial board | Ahead of print | Search | Current Issue | Archives | Submit article | Instructions | Copyright form | Subscribe | Advertise | Contacts
Year : 2020  |  Volume : 14  |  Issue : 2  |  Page : 194-198

Comparision of dexmedetomidine and propofol in patients undergoing laparoscopic cholecystectomy under spinal anesthesia

1 Department of Anaesthesia, GMC, Jammu, Jammu and Kashmir, India
2 Department of Anaesthesia, GMC, Kathua, Jammu and Kashmir, India
3 Department of Anaesthesia, GMC, Doda, Jammu and Kashmir, India
4 Department of Surgery, GMC, Kathua, Jammu and Kashmir, India

Correspondence Address:
Dr. Rajesh Angral
Plot No. 176, Housing Colony, Janipur, Jammu, Jammu and Kashmir
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aer.AER_64_20

Rights and Permissions

Background: Spinal anesthesia (SA) with sedation is considered to be an alternative to general anesthesia for laparoscopic cholecystectomy (LC) in high-risk patients. Ketamine in analgesic dose with propofol or dexmedetomidine infusion provides titratable sedation, hemodynamic stability, and minimum respiratory depression without psychomimetic effects. Aim: To compare the efficacy of ketamine–dexmedetomidine and ketamine-propofol combination in relation to sedation, analgesia, hemodynamic effects, and perioperative side effects. Settings and Design: This was a prospective, randomized single-blind comparative study comprising 100 American Society of Anesthesiologists I, II, and III patients posted for LC. Materials and Methods: Patients were randomized into two groups of 50 patients each. Group KP (ketamine + propofol) received intravenous (i.v.) bolus of injection ketamine 0.5−1 and propofol infusion at 3−1.h−1. Group KD (ketamine + dexmedetomidine) received i.v. bolus of injection ketamine 0.5−1 and dexmedetomidine infusion at 0.4 μ−1.h−1. Parameters observed were vitals, perioperative side effects, time to first rescue analgesia, and return of consciousness. Statistical Analysis: Student's independent t-test was employed for comparing continuous variables. Chi-square test or Fisher's exact test, whichever appropriate, was applied for comparing categorical variables. Results: Duration of analgesia was longer in KD Group (191.2 vs. 173.5 min), and time to regain consciousness was faster in KP Group (14.9 vs. 20.4 min). Conclusion: Both the techniques of sedation are feasible, safe, and comparable, except the duration of analgesia and time to regain consciousness which was longer in KD Group.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded47    
    Comments [Add]    

Recommend this journal