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Year : 2020  |  Volume : 14  |  Issue : 3  |  Page : 428-433

Comparative evaluation of efficacy of preventive analgesia with diclofenac and buprenorphine patch versus single diclofenac patch for postoperative pain following general anesthesia for laparoscopic cholecystectomy

Department of Anaesthesia, ESIC Medical College and Hospital, Hyderabad, Telangana, India

Correspondence Address:
Dr. Ananya Nanda
C/O Department of Anesthesia, ESIC Medical College and Hospital, Sanathnagar, Hyderabad - 500 038, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aer.AER_109_20

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Background: Acute postoperative pain is managed with parenteral and oral medications requiring skilled personnel for administration and vigilance. Previous studies have been done either with transdermal buprenorphine or diclofenac patch separately in mitigating postoperative pain. Aims: The primary aim was to compare pain scores and rescue analgesia requirement. The secondary aims were comparison of side effects, time to mobilization and oral intake start, sedation scores, and satisfaction scores of surgeons and patients receiving transdermal patches of buprenorphine and diclofenac versus placebo and diclofenac patches following laparoscopic cholecystectomy. Settings and Design: This is a randomized double-blinded (1:1), case–control study. Materials and Methods: One hundred patients undergoing laparoscopic cholecystectomies were enrolled for the study. Patients were allocated into two groups by computer-generated randomization: those receiving dual patch of buprenorphine and diclofenac (DP) and those receiving patches of diclofenac and placebo (SP). Outcomes were measured after extubation and at 4, 8, 12, 24, 36, and 48 h after surgery. Statistics: Analysis was done using the Statistical Package for the Social Sciences version 22.0, R environment 3.2.2 for data analysis, and Microsoft Excel to generate graphs and tables. Results: The pain scores and rescue analgesia requirements were significantly higher in group SP compared to group DP. Patient satisfaction scores were better with group DP. No significant difference was found in both the groups concerning sedation scores, side effects, and time to patient mobilization and start of oral intake. Conclusions: Concomitant use of transdermal patches of buprenorphine and diclofenac for postoperative pain in laparoscopic cholecystectomy provides adequate analgesia and patient satisfaction without compromising postoperative recovery.

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