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A study of vitamin D level in critically ill patients and effect of supplementation on clinical outcome

 Department of Anesthesia and Critical Care, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
Manoj Tripathi,
Department of Anesthesia and Critical Care, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aer.AER_83_20

Background: Supplementation of Vitamin-D in Vitamin-D deficient patients may reduce morbidity and mortality in critically ill patients in ICU. Aims and Objectives: The aim of this study is to investigate serum level of Vitamin-D in critically ill patients and supplementation of vitamin-D in deficient patients and finally to compare clinical outcomes between two groups. Settings and Design: Randomized, prospective and comparative study. Materials and Methods: In this study, serum vitamin-D level was investigated in recruited patients and vitamin-D deficient patients were randomly allocated into two groups viz; group-1, group-2. Vitamin-D (sachet CALCIROL 60,000 IU) supplementation was done once a week and twice a week in in group-1 and group-2 respectively, clinical outcomes between two groups were compared in terms of length of ICU stay, need for inotropic support, need for mechanical ventilation and 28 days ICU mortality. Statistical Analysis: Mean and standard deviation were calculated. Test of analysis between two groups was done by t-test and then P value was calculated. Results: No significant difference was found between two groups whether vitamin D supplementation done once or twice weekly (P = 0.24) in terms of length of ICU stay. Patients of group-2 required significantly less inotropic support as compared to group-1 (P= 0.037). There was no significant difference found in duration of mechanical ventilation (P= 0.138) and 28 days ICU mortality (P= 0.284). Conclusion: From the above results we concluded that vitamin D supplementation in high dosages may be started in all critically ill patients, who are deficient in serum vitamin D level to get better clinical outcomes.

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